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KMID : 1161420130160010020
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Journal of Medicinal Food
2013 Volume.16 No. 1 p.20 ~ p.25
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Composition and Evaluation of the Anti-Inflammatory and Anticancer Activities of the Essential Oil from Annona sylvatica A. St.-Hil
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Formagio Anelise S. N.
dos Santos Luiz A. C.
Cardoso Claudia A. L.
Foglio Mary Anny
de Carvalho Joao Ernesto
Andrade-Silva Magaiver
Kassuya Candida A. L.
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Abstract
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The essential oil from the leaves of Annona sylvatica (EOAS) was extracted by hydrodistillation, and the analysis was performed by gas chromatography?mass spectrometry. The main compounds identified in the EOAS were sesquiterpenes, such as hinesol, z-caryophyllene, β-maaliene, γ-gurjunene, silphiperfol-5-en-3-ol, ledol, cubecol-1-epi, and muurola-3,5-diene. Oral administration of the EOAS (20 and 200?mg/kg) and subcutaneous injection of dexamethasone (0.5?mg/kg, reference drug) significantly inhibited carrageenan- and complete Freund's adjuvant?induced mouse paw edema. The anticancer activity the EOAS showed growth inhibitory activity on all cell lines when administered in a high concentration. The EOAS inhibited the growth of human cancer cell lines with GI50 values in the range of 36.04?45.37 μg/mL on all of the cell lines tested. This work describes for the first time the anti-inflammatory and anticancer effects of the essential oil of A. sylvatica and its composition. Considering that drugs currently available for the treatment of inflammatory and cancer conditions show undesirable side-effects, the present results may have clinical relevance and open new possibilities for the development of novel anti-inflammatory and anticancer drugs.
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KEYWORD
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anticancer activity, anti-inflammatory, essential oil, mice
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